Inhibition of the Cell Uptake of Delta and Omicron SARS-CoV-2 Pseudoviruses by N-Acetylcysteine Irrespective of the Oxidoreductive EnvironmentArticle Published on 2022-10-212022-11-16 Journal: Cells [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2-expressing cell ACE2-expressing cells addition Affect alteration angiotensin-converting enzyme 2 antioxidant approach ascorbic acid binding Cell cell internalization cell receptor Comorbidities COVID-19 Delta dose-dependent Effect Effects Environment evaluated hydrogen peroxide inhibit inhibited inhibition mechanism N-acetyl-L-cysteine N-acetylcysteine NAC omicron Oxidant pharmacological Previous studies produced pseudovirus reactive oxygen species Reactive oxygen species. reactive oxygen specy respiratory viral infection risk ROS SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike therapy uptake variant variants variants of SARS-CoV-2 virus uptake [DOI] 10.3390/cells11203313 PMC 바로가기
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 알데히드 기반 트리펩티딜 주요 프로테아제 억제제의 다각적 평가Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cell 293T cells active site aldehyde Amino acid amino acids Antiviral antiviral potency binding carbon cellular complexes conducted covalent inhibitors COVID-19 crystal structure cysteine cytotoxicity develop enzyme exhibited expressed flexible high potency in vitro inhibit inhibitor inhibitors interact low potency M pro main protease N-terminal pathogen Previous studies previous study Pro protease Protease inhibitor residue residues SARS-CoV-2 selected Structural variation structures tolerable Toxicity Treatment treatment of COVID-19 Tripeptides. unnatural Variation X-ray [DOI] 10.1016/j.ejmech.2022.114570 PMC 바로가기 [Article Type] Article
Development and applications of diffusive gradients in thin films for monitoring pharmaceuticals in surface watersResearch article Published on 2022-10-012022-10-05 Journal: Environmental pollution (Barking, Essex : 1987) [Category] 치료제, [키워드] antibiotic antiviral drug antiviral drugs average comparable Concentration contaminant coronavirus disease COVID-19 demonstrated development Diffusive gradients in thin films (DGT) ecological Effect exhibited Health include independent linear pharmaceutical Pharmaceuticals Previous studies provided raised reduce released required robust Treatment [DOI] 10.1016/j.envpol.2022.119979 [Article Type] Research article
Delivery of Antibody-Like Molecules, Monobodies, Capable of Binding with SARS-CoV-2 Virus Nucleocapsid Protein, into Target CellsArticle Published on 2022-10-012022-11-15 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 진단, [키워드] antibody-like molecules C-terminus cellular cellular thermal shift assay delivery demonstrated E. coli expressed fluorescent fused HEK293T cell highest affinity Interaction molecules monobody nucleocapsid nucleocapsid protein penetration peptide Previous studies produced Protein replacement resulting S10 shuttle peptide SARS-CoV-2 selected significantly target target cells TAT TAT peptide the SARS-CoV-2 thermophoresis. transfected with [DOI] 10.1134/S1607672922050088 PMC 바로가기
“Lymphocyte * Neutrophil” count decreased in SARS-CoV-2 Omicron patients in Shanghai with no significant change in CRP and SAAArticle Published on 2022-10-012022-11-16 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 변종, [키워드] all subject Analysis analyzed AUC Blood can be used CBC changes changes in Clinical data collected contrary correlated CRP cutoff value Diagnosis diagnostic differential diagnosis EOS excluded Fever had no in some inflammatory indicator lymphocyte neutrophil NLR not significantly different omicron Omicron. Patient patients patients with SARS-CoV-2 PCT positive Previous studies prognosis of patients SAA SARS-CoV-2 selected Sensitivity and specificity Shanghai significantly significantly higher significantly lower the SARS-CoV-2 Toxicity variant was selected WBC while [DOI] 10.1002/jcla.24671 PMC 바로가기
Comparison of epidemiological characteristics and transmissibility of different strains of COVID-19 based on the incidence data of all local outbreaks in China as of March 1, 2022Article Published on 2022-09-152022-11-15 Journal: Frontiers in Public Health [Category] SARS, 변종, 진단, [키워드] CDC center change Characteristics China Chinese Cluster collected concerning Control coronavirus 2 COVID-19 decrease Delta delta variant diagnosed effective effective reproduction number Epidemic epidemiological Evolution highest illness onset incidence indicated Indicator investigator Kruskal-Wallis local outbreak mainland more difficult Mutation occurred omicron Omicron variant outbreak platform prevention Previous studies ranged RDT reported Reproduction number respiratory rising SARS-CoV-2 statistically significant strain Strains suppress the disease Transmissibility undergo variant Variant. variants virus were used [DOI] 10.3389/fpubh.2022.949594 PMC 바로가기
Structural- and Site-Specific N- Glycosylation Characterization of COVID-19 Virus Spike with StrucGPArticle Published on 2022-09-132022-11-15 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] addition Algorithm analyzed characterization COVID-19 COVID-19 virus glycan glycosylation Infection Mannose 6-phosphate mapped motif Previous studies previous study Protein residues SARS-CoV-2 Sequencing spike Structure structures Support the S protein trimer [DOI] 10.1021/acs.analchem.2c02265 PMC 바로가기
Household Secondary Transmission of the Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant From a Community Cluster in a Nursery in Japan중증급성호흡기증후군 코로나바이러스 2 알파 변종 일본 보육원 커뮤니티 클러스터에서 가구 이차 전파Article Published on 2022-09-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults Alpha variant analyzed children Cluster coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 exhibited greater high risk household household SAR increase in Increased investigated Japan nursery patients Previous studies reported respiratory SARS SARS-CoV-2 secondary secondary attack rate secondary transmission severe acute respiratory syndrome Coronavirus spread to Transmissibility Transmission transmission route Transmission routes variants variants of concern virus VoC VOCs were infected whole-genome sequencing [DOI] 10.1097/INF.0000000000003607 PMC 바로가기 [Article Type] Article
Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study코로나바이러스 질병 2019(COVID-19) 동안 어린이의 폐렴구균 질병 감소, 지속적인 폐렴구균 감염에도 불구하고 계절성 호흡기 바이러스 억제와 관련된 이스라엘의 유행성: 전향적 코호트 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] activity Adenovirus adjusted age alveolar Chain Reaction chest X-ray chest X-rays children Cohort colonization COVID-19 COVID-19 pandemic Decline declined density disappearance disease distribution Ethnicity expected followed by human metapneumovirus Hypothesis implicated incidence incidence rate Influenza influenza viruses invasive pneumococcal disease lockdown lower respiratory infections magnitude métapneumovirus monthly rate nasopharyngeal Nonpharmaceutical interventions nonpneumonia parainfluenza Pathogens persistent pneumococcal pneumococcal pneumoniae pneumococcus Pneumonia pneumoniae polymerase chain polymerase chain reaction Prevalence Previous studies previous study Prospective reduced reduction reductions respiratory respiratory infection respiratory infections respiratory syncytial virus respiratory virus respiratory viruses respiratory viruses. resulting rhinovirus SARS-CoV-2 seasonal serotype suppression Surveillance Transmission [DOI] 10.1093/cid/ciab1014 PMC 바로가기 [Article Type] Article
Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood전혈에서 중증 급성 호흡기 증후군 코로나바이러스 2-특이적 T 세포 분석을 위한 신속한 사이토카인 방출 분석Article Published on 2022-08-242022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-receptor-binding domain antibody Blood samples characteristic clinical complicate Complication controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine cytokine Cytokine release assay diagnosed Diagnosis Diagnostic accuracy Donor EudraCT evaluated exhibited high accuracy IgG IgG levels Immunoglobulin Immunoglobulin G induction Infection interferon interferon γ memory memory response nucleocapsid Patient peptide peptides plasma Previous studies protocol Rapid receiver receiver operating characteristic Region Release remained respiratory SARS-CoV-2 seropositive serum severe acute respiratory syndrome Coronavirus Spike. stimulated study participant supernatant T cells T-cell T-cell immunity Trial vaccine doses waned Whole blood [DOI] 10.1093/infdis/jiac005 PMC 바로가기 [Article Type] Article